Author: Meytal Galilee; Akram Alian
Title: Multimerization of HIV-1 integrase hinges on conserved SH3-docking platforms Document date: 2018_4_16
ID: 4fuxbte0_22
Snippet: The fact that IN regulates not only viral integration but also the assembly and maturation of virus particles (9, 22) , accentuates the prominence of this target. Whereas the peptide used in this study may not, per se, provide a lead hit for this anti-IN strategy, our work underscores the overlooked SH3-docking platform of HIV-1 IN as a potential therapeutic target for future anti-IN allosteric inhibitors......
Document: The fact that IN regulates not only viral integration but also the assembly and maturation of virus particles (9, 22) , accentuates the prominence of this target. Whereas the peptide used in this study may not, per se, provide a lead hit for this anti-IN strategy, our work underscores the overlooked SH3-docking platform of HIV-1 IN as a potential therapeutic target for future anti-IN allosteric inhibitors.
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