Author: Walczak, Piotr; Janowski, Miroslaw
Title: The COVIDâ€19 Menace Cord-id: 61o3nu6d Document date: 2021_5_7
ID: 61o3nu6d
Snippet: Coronavirus disease 2019 (COVIDâ€19) is caused by the new severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2), which binds to ectoenzyme angiotensinâ€converting enzyme 2. It is very contagious and is spreading rapidly around the world. Until now, coronaviruses have mainly been associated with the aerodigestive tract due to the presence of a monobasic cleavage site for the resident transmembrane serine protease 2. Notably, SARSâ€CoVâ€2 is equipped with a second, polybasic cleavag
Document: Coronavirus disease 2019 (COVIDâ€19) is caused by the new severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2), which binds to ectoenzyme angiotensinâ€converting enzyme 2. It is very contagious and is spreading rapidly around the world. Until now, coronaviruses have mainly been associated with the aerodigestive tract due to the presence of a monobasic cleavage site for the resident transmembrane serine protease 2. Notably, SARSâ€CoVâ€2 is equipped with a second, polybasic cleavage site for the ubiquitous furin protease, which may determine the widespread tissue tropism. Furthermore, the terminal sequence of the furinâ€cleaved spike protein also binds to neuropilin receptors. Clinically, there is enormous variability in the severity of the disease. Severe consequences are seen in a relatively small number of patients, most show moderate symptoms, but asymptomatic cases, especially among young people, drive disease spread. Unfortunately, the number of local infections can quickly build up, causing disease outbreaks suddenly exhausting health services’ capacity. Therefore, COVIDâ€19 is dangerous and unpredictable and has become the most serious threat for generations. Here, the latest research on COVIDâ€19 is summarized, including its spread, testing methods, organâ€specific complications, the role of comorbidities, longâ€term consequences, mortality, as well as a new hope for immunity, drugs, and vaccines.
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