Author: Qiang Zeng; Yong-zhe Li; Gang Huang; Wei Wu; Sheng-yong Dong; Yang Xu
Title: Mortality of COVID-19 is Associated with Cellular Immune Function Compared to Immune Function in Chinese Han Population Document date: 2020_3_10
ID: 1k64g7m3_36
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.08.20031229 doi: medRxiv preprint SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2. 8 Therefore, it is necessary to further study whether lymphocytes have ACE2 receptor and TMPRSS2 expression during the developmental stage since the PLD exists. A SARS-CoV-2 RT-PCR assay for lymphocyte subsets in severe or critical cases should be followe.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.08.20031229 doi: medRxiv preprint SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2. 8 Therefore, it is necessary to further study whether lymphocytes have ACE2 receptor and TMPRSS2 expression during the developmental stage since the PLD exists. A SARS-CoV-2 RT-PCR assay for lymphocyte subsets in severe or critical cases should be followed up. Our findings also suggest that lymphocyte subsets should be analyzed at admission immediately no matter how COVID-19 affected lymphocytes through directly or indirectly. When patients are confirmed as COVID-19, clinicians should order tests for lymphocyte subsets in order to intervene early in the consequences of the PLD.
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