Author: Lu, Xiaoyan; Rowe, Lori A.; Frace, Michael; Stevens, James; Abedi, Glen R.; Elnile, Osman; Banassir, Taleb; Alâ€Masri, Malak; Watson, John T.; Assiri, Abdullah; Erdman, Dean D.
Title: Spike gene deletion quasispecies in serum of patient with acute MERSâ€CoV infection Cord-id: ifdgl2bj Document date: 2016_8_22
ID: ifdgl2bj
Snippet: The spike glycoprotein of the Middle East respiratory coronavirus (MERSâ€CoV) facilitates receptor binding and cell entry. During investigation of a multiâ€facility outbreak of MERSâ€CoV in Taif, Saudi Arabia, we identified a mixed population of wildâ€type and variant sequences with a large 530 nucleotide deletion in the spike gene from the serum of one patient. The out of frame deletion predicted loss of most of the S2 subunit of the spike protein leaving the S1 subunit with an intact recep
Document: The spike glycoprotein of the Middle East respiratory coronavirus (MERSâ€CoV) facilitates receptor binding and cell entry. During investigation of a multiâ€facility outbreak of MERSâ€CoV in Taif, Saudi Arabia, we identified a mixed population of wildâ€type and variant sequences with a large 530 nucleotide deletion in the spike gene from the serum of one patient. The out of frame deletion predicted loss of most of the S2 subunit of the spike protein leaving the S1 subunit with an intact receptor binding domain. This finding documents human infection with a novel genetic variant of MERSâ€CoV present as a quasispecies. J. Med. Virol. 89:542–545, 2017. © 2016 Wiley Periodicals, Inc.
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