Selected article for: "fit model and model model"
Author: William Fitzsimmons; Robert J. Woods; John T. McCrone; Andrew Woodman; Jamie J. Arnold; Madhumita Yennawar; Richard Evans; Craig E. Cameron; Adam S. Lauring
Title: A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus
  • Document date: 2018_4_27
    • ID: 8p24gszj_77
    Snippet: The premise of the speed-fidelity tradeoff is that the outcome of competition between two viral 843 strains will be determined by two opposing forces -the speed with which the genome can be 844 replicated and the error rate of replication. The faster genome replication happens, the more 845 errors that occur and the greater the mutational load. In this scenario an optimal competitive 846 fitness will be achieved exactly where the increase in fitn.....
    Document: The premise of the speed-fidelity tradeoff is that the outcome of competition between two viral 843 strains will be determined by two opposing forces -the speed with which the genome can be 844 replicated and the error rate of replication. The faster genome replication happens, the more 845 errors that occur and the greater the mutational load. In this scenario an optimal competitive 846 fitness will be achieved exactly where the increase in fitness is counterbalanced by decrease in 847 fitness from excess mutational load. Here we present a simple mathematical model to 848 demonstrate this tradeoff, and fit the model to the experimental data.

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