Author: Mohamed, Aia; Rogers, Thomas R.; Talento, Alida Fe
Title: COVID-19 Associated Invasive Pulmonary Aspergillosis: Diagnostic and Therapeutic Challenges Cord-id: 79smxr1v Document date: 2020_7_22
ID: 79smxr1v
Snippet: Aspergillus co-infection in patients with severe coronavirus disease 2019 (COVID-19) pneumonia, leading to acute respiratory distress syndrome, has recently been reported. To date, 38 cases have been reported, with other cases most likely undiagnosed mainly due to a lack of clinical awareness and diagnostic screening. Importantly, there is currently no agreed case definition of COVID-19 associated invasive pulmonary aspergillosis (CAPA) that could aid in the early detection of this co-infection.
Document: Aspergillus co-infection in patients with severe coronavirus disease 2019 (COVID-19) pneumonia, leading to acute respiratory distress syndrome, has recently been reported. To date, 38 cases have been reported, with other cases most likely undiagnosed mainly due to a lack of clinical awareness and diagnostic screening. Importantly, there is currently no agreed case definition of COVID-19 associated invasive pulmonary aspergillosis (CAPA) that could aid in the early detection of this co-infection. Additionally, with the global emergence of triazole resistance, we emphasize the importance of antifungal susceptibility testing in order to ensure appropriate antifungal therapy. Herein is a review of 38 published CAPA cases, which highlights the diagnostic and therapeutic challenges posed by this novel fungal co-infection.
Search related documents:
Co phrase search for related documents- acute ards respiratory distress syndrome and additional imaging: 1, 2
- acute ards respiratory distress syndrome and low sensitivity: 1, 2, 3, 4
- acute ards respiratory distress syndrome and lung biopsy: 1, 2, 3, 4, 5, 6, 7, 8
- acute ards respiratory distress syndrome and lung damage: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72
- acute ards respiratory distress syndrome and lung tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- adaptive immune response and local immune response: 1, 2, 3
- adaptive immune response and lung damage: 1, 2, 3, 4, 5, 6
- adaptive immune response and lung tissue: 1, 2, 3, 4, 5, 6, 7
- additional imaging and low sensitivity: 1
- additional imaging and lung tissue: 1
- local epidemiology and low sensitivity: 1
- local immune response and lung damage: 1, 2
- local immune response and lung tissue: 1, 2, 3
- low sensitivity and lung damage: 1, 2
- low sensitivity and lung tissue: 1, 2
Co phrase search for related documents, hyperlinks ordered by date