Selected article for: "fungal infection and invasive aspergillosis"
Author: Mohamed, Aia; Rogers, Thomas R.; Talento, Alida Fe
Title: COVID-19 Associated Invasive Pulmonary Aspergillosis: Diagnostic and Therapeutic Challenges
  • Cord-id: 79smxr1v
  • Document date: 2020_7_22
    • ID: 79smxr1v
    Snippet: Aspergillus co-infection in patients with severe coronavirus disease 2019 (COVID-19) pneumonia, leading to acute respiratory distress syndrome, has recently been reported. To date, 38 cases have been reported, with other cases most likely undiagnosed mainly due to a lack of clinical awareness and diagnostic screening. Importantly, there is currently no agreed case definition of COVID-19 associated invasive pulmonary aspergillosis (CAPA) that could aid in the early detection of this co-infection.
    Document: Aspergillus co-infection in patients with severe coronavirus disease 2019 (COVID-19) pneumonia, leading to acute respiratory distress syndrome, has recently been reported. To date, 38 cases have been reported, with other cases most likely undiagnosed mainly due to a lack of clinical awareness and diagnostic screening. Importantly, there is currently no agreed case definition of COVID-19 associated invasive pulmonary aspergillosis (CAPA) that could aid in the early detection of this co-infection. Additionally, with the global emergence of triazole resistance, we emphasize the importance of antifungal susceptibility testing in order to ensure appropriate antifungal therapy. Herein is a review of 38 published CAPA cases, which highlights the diagnostic and therapeutic challenges posed by this novel fungal co-infection.

    Search related documents:
    Co phrase search for related documents
    • acute ards respiratory distress syndrome and additional imaging: 1, 2
    • acute ards respiratory distress syndrome and low sensitivity: 1, 2, 3, 4
    • acute ards respiratory distress syndrome and lung biopsy: 1, 2, 3, 4, 5, 6, 7, 8
    • acute ards respiratory distress syndrome and lung damage: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • acute ards respiratory distress syndrome and lung tissue: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
    • adaptive immune response and local immune response: 1, 2, 3
    • adaptive immune response and lung damage: 1, 2, 3, 4, 5, 6
    • adaptive immune response and lung tissue: 1, 2, 3, 4, 5, 6, 7
    • additional imaging and low sensitivity: 1
    • additional imaging and lung tissue: 1
    • local epidemiology and low sensitivity: 1
    • local immune response and lung damage: 1, 2
    • local immune response and lung tissue: 1, 2, 3
    • low sensitivity and lung damage: 1, 2
    • low sensitivity and lung tissue: 1, 2