Selected article for: "mouse model and rv infection"
Author: Aran Singanayagam; Joseph Footitt; Benjamin T Kasdorf; Matthias Marczynski; Michael T Cross; Lydia J Finney; Maria-Belen Trujillo Torralbo; Maria Calderazzo; Jie Zhu; Julia Aniscenko; Thomas B Clarke; Philip L Molyneaux; Nathan W Bartlett; Miriam F Moffatt; William O Cookson; Jadwiga Wedzicha; Christopher M Evans; Oliver Lieleg; Patrick Mallia; Sebastian L Johnston
Title: MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation
  • Document date: 2019_7_22
    • ID: gg2ctmn7_28
    Snippet: To further confirm a functional role for MUC5AC in RV-induced inflammation and exacerbation severity, we evaluated the in vivo effects of exogenous MUC5AC glycoprotein in the mouse model of RV infection (Fig.4a) . Exogenous MUC5AC administration alone had no effect on BAL inflammatory cell numbers (Fig.4b) or pro-inflammatory chemokine or cytokine concentrations ( Fig.4c&d ) but MUC5AC administration (0.5mg/mL) enhanced RVinduced airway inflammat.....
    Document: To further confirm a functional role for MUC5AC in RV-induced inflammation and exacerbation severity, we evaluated the in vivo effects of exogenous MUC5AC glycoprotein in the mouse model of RV infection (Fig.4a) . Exogenous MUC5AC administration alone had no effect on BAL inflammatory cell numbers (Fig.4b) or pro-inflammatory chemokine or cytokine concentrations ( Fig.4c&d ) but MUC5AC administration (0.5mg/mL) enhanced RVinduced airway inflammation including increased total cell and neutrophil numbers (Fig. 4b) ,

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