Author: Lee, Heung Kyu; Iwasaki, Akiko
Title: Autophagy and antiviral immunity Cord-id: 7upksc9f Document date: 2008_2_1
ID: 7upksc9f
Snippet: Autophagy is an ancient pathway designed to maintain cellular homeostasis by degrading long-lived proteins and organelles in the cytosol. Recent studies demonstrate that autophagy is utilized by the cells of the innate and adaptive immune systems to combat viral infections. Autophagy plays a key role in recognizing signatures of viral infection, and represents a critical effector mechanism to restrict viral replication. On the other hand, autophagosomes have been exploited by certain viruses as
Document: Autophagy is an ancient pathway designed to maintain cellular homeostasis by degrading long-lived proteins and organelles in the cytosol. Recent studies demonstrate that autophagy is utilized by the cells of the innate and adaptive immune systems to combat viral infections. Autophagy plays a key role in recognizing signatures of viral infection, and represents a critical effector mechanism to restrict viral replication. On the other hand, autophagosomes have been exploited by certain viruses as a niche for viral replication. Furthermore, autophagy can be used to deliver endogenous viral antigens to the MHC class II loading compartment, allowing activation of CD4 T cells. In this review, we describe recent advances in the field of autophagy as it relates to innate and adaptive antiviral immune responses.
Search related documents:
Co phrase search for related documents- acid inducible gene and adaptive innate: 1, 2
- acid inducible gene and adaptive innate immunity: 1, 2
- adaptive immune response and lps stimulation: 1
- adaptive immune response and lymphoid tissue: 1, 2
- adaptive immune response and lysosomal degradation: 1
- adaptive immune response and macrophage derive: 1
- adaptive innate and lps stimulation: 1, 2
- adaptive innate and lymphoid tissue: 1, 2, 3, 4
- adaptive innate and lysosomal degradation: 1, 2, 3, 4, 5, 6, 7, 8
- adaptive innate immunity and lymphoid tissue: 1
- adaptive innate immunity and lysosomal degradation: 1, 2, 3
- additional molecular mechanism and lysosome fusion: 1
Co phrase search for related documents, hyperlinks ordered by date