Recoverable peroxidase-like Fe(3)O(4)@MoS(2)-Ag nanozyme with enhanced antibacterial ability

Wei, Feng; Cui, Xinyu; Wang, Zhao; Dong, Changchang; Li, Jiadong; Han, Xiaojun

Antibacterial agents with enzyme-like properties and bacteria-binding ability have provided an alternative method to efficiently disinfect drug-resistance microorganism. Herein, a Fe(3)O(4)@MoS(2)-Ag nanozyme with defect-rich rough surface was constructed by a simple hydrothermal method and in-situ photodeposition of Ag nanoparticles. The nanozyme exhibited good antibacterial performance against E. coli (∼ 69.4%) by the ROS destruction and release of Ag(+), while the nanozyme could further achieve an excellent synergistic disinfection (∼ 100 %) by combining with the near-infrared photothermal property of Fe(3)O(4)@MoS(2)-Ag. The antibacterial mechanism study showed that the antibacterial process was determined by the collaborative work of peroxidase-like activity, photothermal effect and leakage of Ag(+). The defect-rich rough surface of MoS(2) layers facilitated the capture of bacteria, which enhanced the accurate and rapid attack of ·OH and Ag(+) to the membrane of E. coli with the assistance of local hyperthermia. This method showed broad-spectrum antibacterial performance against Gram-negative bacteria, Gram-positive bacteria, drug-resistant bacteria and fungal bacteria. Meanwhile, the magnetism of Fe(3)O(4) was used to recycle the nanozyme. This work provided the motivation to engineer the nanozyme for efficient disinfection treatment.