Author: Yadi Zhou; Yuan Hou; Jiayu Shen; Yin Huang; William Martin; Feixiong Cheng
Title: Network-based Drug Repurposing for Human Coronavirus Document date: 2020_2_5
ID: b4mdiont_10
Snippet: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.03.20020263 doi: medRxiv preprint spike is a transmembrane glycoprotein that plays a pivotal role in mediating viral infection through binding the host receptor [29, 30] . Figure 2D shows the 3D structure of the spike protein bound with the host receptor angiotensin converting enznyme2 (ACE2) in SARS-CoV (PDB ID: 6ACK). A recent study sho.....
Document: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.03.20020263 doi: medRxiv preprint spike is a transmembrane glycoprotein that plays a pivotal role in mediating viral infection through binding the host receptor [29, 30] . Figure 2D shows the 3D structure of the spike protein bound with the host receptor angiotensin converting enznyme2 (ACE2) in SARS-CoV (PDB ID: 6ACK). A recent study showed that 2019-nCoV is able to utilize ACE2 as an entry receptor in ACE2-expressing cells [31] , suggesting potential drug targets for therapeutic development. In addition, the nucleocapsid is also an important subunit for packaging the viral genome through protein oligomerization [32] , and the single nucleocapsid structure was shown in Figure 2E .
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