Author: Yadi Zhou; Yuan Hou; Jiayu Shen; Yin Huang; William Martin; Feixiong Cheng
Title: Network-based Drug Repurposing for Human Coronavirus Document date: 2020_2_5
ID: b4mdiont_10
Snippet: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.03.20020263 doi: medRxiv preprint spike is a transmembrane glycoprotein that plays a pivotal role in mediating viral infection through binding the host receptor [29, 30] . Figure 2D shows the 3D structure of the spike protein bound with the host receptor angiotensin converting enznyme2 (ACE2) in SARS-CoV (PDB ID: 6ACK). A recent study sho.....
Document: is the (which was not peer-reviewed) The copyright holder for this preprint . https://doi.org/10.1101/2020.02.03.20020263 doi: medRxiv preprint spike is a transmembrane glycoprotein that plays a pivotal role in mediating viral infection through binding the host receptor [29, 30] . Figure 2D shows the 3D structure of the spike protein bound with the host receptor angiotensin converting enznyme2 (ACE2) in SARS-CoV (PDB ID: 6ACK). A recent study showed that 2019-nCoV is able to utilize ACE2 as an entry receptor in ACE2-expressing cells [31] , suggesting potential drug targets for therapeutic development. In addition, the nucleocapsid is also an important subunit for packaging the viral genome through protein oligomerization [32] , and the single nucleocapsid structure was shown in Figure 2E .
Search related documents:
Co phrase search for related documents- drug target and host receptor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18
- drug target and host receptor bind: 1, 2
- drug target and host receptor bind spike protein: 1
- drug target and pivotal role: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23
- drug target and potential therapeutic development drug target: 1
- drug target and protein oligomerization: 1
- drug target and recent study: 1, 2, 3, 4
- drug target and spike protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- drug target and therapeutic development: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- drug target and therapeutic development drug target: 1, 2, 3, 4, 5, 6, 7, 8, 9
- drug target and transmembrane glycoprotein: 1, 2, 3
- drug target and viral genome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21
- drug target and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- entry receptor and host receptor bind spike protein: 1, 2, 3, 4, 5
- entry receptor and spike protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- entry receptor and therapeutic development: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- entry receptor and transmembrane glycoprotein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12
- entry receptor and viral genome: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- entry receptor and viral infection: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
Co phrase search for related documents, hyperlinks ordered by date