Author: Yadi Zhou; Yuan Hou; Jiayu Shen; Yin Huang; William Martin; Feixiong Cheng
Title: Network-based Drug Repurposing for Human Coronavirus Document date: 2020_2_5
ID: b4mdiont_15
Snippet: We found that 47 human proteins (39%, blue nodes in Figure 3A ) can be targeted by at least one approved drug or experimental drug under clinical trial. For example, GSK3B, DPP4, SMAD3, PARP1, and IKBKB are the most targetable proteins. The high druggability of HCoV-host interactome motivates us to develop a therapeutic strategy by specifically targeting cellular proteins associated with HCoVs, such as drug repurposing......
Document: We found that 47 human proteins (39%, blue nodes in Figure 3A ) can be targeted by at least one approved drug or experimental drug under clinical trial. For example, GSK3B, DPP4, SMAD3, PARP1, and IKBKB are the most targetable proteins. The high druggability of HCoV-host interactome motivates us to develop a therapeutic strategy by specifically targeting cellular proteins associated with HCoVs, such as drug repurposing.
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