Mutations, Recombination and Insertion in the Evolution of 2019-nCoV

Aiping Wu; Peihua Niu; Lulan Wang; Hangyu Zhou; Xiang Zhao; Wenling Wang; Jingfeng Wang; Chengyang Ji; Xiao Ding; Xianyue Wang; Roujian Lu; Sarah Gold; Saba Aliyari; Shilei Zhang; Ellee Vikram; Angela Zou; Emily Lenh; Janet Chen; Fei Ye; Na Han; Yousong Peng; Haitao Guo; Guizhen Wu; Taijiao Jiang; Wenjie Tan; Genhong Cheng

The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.02.29.971101 doi: bioRxiv preprint several independent strains in both group 1 and group 2, which will lead to L3606F amino acid substitution within the orf1ab polyprotein ( Fig S3) . It is not clear if the common mutation both in group 1 and group 2 strains at 10818 site has any growth advantage but pangolin and bat CoV have L3606V substitution at the same position ( Fig S3) . When the group 1 and group 2 strains were placed onto geographic map (Fig 2B) , it seems that 5 both groups have been transmitted to most countries and regions with reported 2019-nCoV cases with few exceptions, suggesting these two groups are rapidly transmissible.