Selected article for: "cleavage site and sequence comparison"
Author: Aiping Wu; Peihua Niu; Lulan Wang; Hangyu Zhou; Xiang Zhao; Wenling Wang; Jingfeng Wang; Chengyang Ji; Xiao Ding; Xianyue Wang; Roujian Lu; Sarah Gold; Saba Aliyari; Shilei Zhang; Ellee Vikram; Angela Zou; Emily Lenh; Janet Chen; Fei Ye; Na Han; Yousong Peng; Haitao Guo; Guizhen Wu; Taijiao Jiang; Wenjie Tan; Genhong Cheng
Title: Mutations, Recombination and Insertion in the Evolution of 2019-nCoV
  • Document date: 2020_3_2
    • ID: jmrg4oeb_26
    Snippet: Although the exact mechanisms responsible for such a high infection rates remains 15 to be further investigated, our data on both recombination in the RBD and the unique furin or TMPRSS2 cleavage site insertion between the S1 and S2 domains of the spike protein may explain why the transmission of this newly emerged virus is significantly increased compared to the related beta-coronaviruses, including SARS and MERS. Further tracking the genome mut.....
    Document: Although the exact mechanisms responsible for such a high infection rates remains 15 to be further investigated, our data on both recombination in the RBD and the unique furin or TMPRSS2 cleavage site insertion between the S1 and S2 domains of the spike protein may explain why the transmission of this newly emerged virus is significantly increased compared to the related beta-coronaviruses, including SARS and MERS. Further tracking the genome mutations with additional strains of 2019-nCoV isolated from patients in 20 different locations at different time points will provide insights to understand the molecular evolution of this rapid spreading viruses. More importantly, comparison of protein sequence and structural differences between 2019-nCoV and other beta coronaviruses author/funder. All rights reserved. No reuse allowed without permission.

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