Selected article for: "low high dose and viral dose"
Author: Richard, Mathilde; Knauf, Sascha; Lawrence, Philip; Mather, Alison E.; Munster, Vincent J.; Müller, Marcel A.; Smith, Derek; Kuiken, Thijs
Title: Factors determining human-to-human transmissibility of zoonotic pathogens via contact. Human-to-human contact transmission of pathogens
  • Cord-id: 890mltl8
  • Document date: 2017_2_1
    • ID: 890mltl8
    Snippet: The pandemic potential of zoonotic pathogens lies in their ability to become efficiently transmissible amongst humans. Here, we focus on contact-transmitted pathogens and discuss the factors, at the pathogen, host and environmental levels that promote or hinder their human-to-human transmissibility via the following modes of contact transmission: skin contact, sexual contact, respiratory contact and multiple route contact. Factors common to several modes of transmission were immune evasion, high
    Document: The pandemic potential of zoonotic pathogens lies in their ability to become efficiently transmissible amongst humans. Here, we focus on contact-transmitted pathogens and discuss the factors, at the pathogen, host and environmental levels that promote or hinder their human-to-human transmissibility via the following modes of contact transmission: skin contact, sexual contact, respiratory contact and multiple route contact. Factors common to several modes of transmission were immune evasion, high viral load, low infectious dose, crowding, promiscuity, and co-infections; other factors were specific for a pathogen or mode of contact transmission. The identification of such factors will lead to a better understanding of the requirements for human-to-human spread of pathogens, as well as improving risk assessment of newly emerging pathogens.

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