Author: Kwang Su Kim; Keisuke Ejima; Yusuke Ito; Shoya Iwanami; Hirofumi Ohashi; Yoshiki Koizumi; Yusuke Asai; Shinji Nakaoka; Koichi Watashi; Robin N Thompson; Shingo Iwami
Title: Modelling SARS-CoV-2 Dynamics: Implications for Therapy Document date: 2020_3_27
ID: 09r4d3nu_42
Snippet: vaccination (13, 14)); (ii) blocking virus production (such as lopinavir/ritonavir (HIV 281 protease inhibitors), remdesivir (an anti-Ebola virus candidate) and other nucleoside 282 analogues, and interferon (15, 16) CoV-2 therapy, the median parameter sets were used to predict the expected 286 outcome of each therapy. In other words, even though no drug administration trials 287 have been conducted yet, we were able to infer the efficacy of each.....
Document: vaccination (13, 14)); (ii) blocking virus production (such as lopinavir/ritonavir (HIV 281 protease inhibitors), remdesivir (an anti-Ebola virus candidate) and other nucleoside 282 analogues, and interferon (15, 16) CoV-2 therapy, the median parameter sets were used to predict the expected 286 outcome of each therapy. In other words, even though no drug administration trials 287 have been conducted yet, we were able to infer the efficacy of each drug treatment 288 based on our in silico experiments. We implemented the different mechanisms of 289 action in the model as follows: 290 (i) Blocking de novo infection. The antiviral effect of blocking de novo infection 291 therapy (0 < ≤ 1. = 1 implies de novo infection is 100% inhibited) initiated at * 292 days after symptom onset was modelled by assuming: 293
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