Are colorectal cancer patients at risk for COVID-19 infection during the postoperative period? The Covid-GRECCAR study

Tuech, Jean-Jacques; Manceau, Gilles; Ouaissi, Mehdi; Denet, Christine; Chau, Amélie; Kartheuser, Alex; Desfourneaux, Véronique; Duchalais, Emilie; Bertrand, Martin; Badic, Bogdan; Alves, Arnaud; Ceribelli, Cecilia; Venara, Aurelien; Mege, Diane; Mauvais, François; Dumont, Fréderic; Mabrut, Jean-Yves; Lakkis, Zaher; Cotte, Eddy; Meillat, Helene

INTRODUCTION: During the COVID-19 pandemic, cancer patients have been regarded as having a high risk of severe events if they are infected with SARS-CoV-2, particularly those under medical or surgical treatment. The aim of this study was to assess the posttreatment risk of infection by SARS-CoV-2 in a population of patients operated on for colorectal cancer 3 months before the COVID-19 outbreak and who after hospitalization returned to an environment where the virus was circulating. MATERIALS AND METHODS: This French, multicenter cohort study included consecutive patients undergoing elective surgery for colorectal cancer between January 1 and March 31, 2020, at 19 GRECCAR hospitals. The outcome was the rate of COVID-19 infection in this group of patients who were followed until June 15, 2020. RESULTS: This study included 448 patients, 262 male (58.5%) and 186 female (41.5%), who underwent surgery for colon cancer (n = 290, 64.7%), rectal cancer (n = 155, 34.6%), or anal cancer (n = 3, 0.7%). The median age was 68 years (19–95). Comorbidities were present in nearly half of the patients, 52% were at least overweight, and the median BMI was 25 (12–42). At the end of the study, 448 were alive. Six patients (1.3%) developed COVID-19 infection; among them, 3 were hospitalized in the conventional ward, and none of them died. CONCLUSION: The results are reassuring, with only a 1.3% infection rate and no deaths related to COVID-19. We believe that we can operate on colorectal cancer patients without additional mortality from COVID-19, applying all measures aimed at reducing the risk of infection.