Author: Mohamed Khosroshahi, Leila; Rezaei, Nima
Title: Dysregulation of the immune response in coronavirus disease 2019 Cord-id: 8w0vd9ub Document date: 2020_12_11
ID: 8w0vd9ub
Snippet: Severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) can trigger a cytokine storm in the pulmonary tissue by releasing various types of mediators, leading to acute respiratory distress syndrome (ARDS). Increased neutrophilâ€toâ€lymphocyte ratio, as well as CD4+ T lymphopenia, is reported in cases with novel coronavirus disease (COVIDâ€19), meanwhile, lymphopenia is a significant finding in the majority of COVIDâ€19 cases with a severe phenotype. Moreover, excessive activation of
Document: Severe acute respiratory syndrome coronavirus 2 (SARSâ€CoVâ€2) can trigger a cytokine storm in the pulmonary tissue by releasing various types of mediators, leading to acute respiratory distress syndrome (ARDS). Increased neutrophilâ€toâ€lymphocyte ratio, as well as CD4+ T lymphopenia, is reported in cases with novel coronavirus disease (COVIDâ€19), meanwhile, lymphopenia is a significant finding in the majority of COVIDâ€19 cases with a severe phenotype. Moreover, excessive activation of monocyte/macrophage and cytokine storms are associated with the severity of the disease and the related complications in SARSâ€CoVâ€2 infection. Understanding the immune response dysregulation in COVIDâ€19 is essential to develop more effective diagnostic, therapeutic, and prophylactic strategies in this pandemic.
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