Author: Stejskal, V.; Šteiner, I.; Manethová, M.
Title: Pathology of covid-19 Cord-id: 9elgmwnf Document date: 2021_1_1
ID: 9elgmwnf
Snippet: In covid-19, the basic lesion is interstitial pneumonia presenting as diffuse alveolar damage. However, unlike DAD/ARDS from other causes, there are several rather specific histopathological features: in the lung parenchyma, there is frequently a combination of all stages of DAD - acute, subacute, and chronic;platelet, and fibrin-rich thrombi are found in all types of pulmonary vessels - microcirculation, arteries, and veins, with formation of lung infarctions;the inflammation has a marked hemor
Document: In covid-19, the basic lesion is interstitial pneumonia presenting as diffuse alveolar damage. However, unlike DAD/ARDS from other causes, there are several rather specific histopathological features: in the lung parenchyma, there is frequently a combination of all stages of DAD - acute, subacute, and chronic;platelet, and fibrin-rich thrombi are found in all types of pulmonary vessels - microcirculation, arteries, and veins, with formation of lung infarctions;the inflammation has a marked hemorrhagic character - alveolar bleeding;presence of atypical activated type II pneumocytes;unusual ("naked") megakaryocytes within the microvasculature;presence of virions in lung cells;and tendency to bacterial or fungal superinfection. In the heart, no specific, reproducible histopathology of covid-19 myocardial injury has been shown at autopsy and the rates of fatal myocarditis are low.
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