Author: Umar Faruq Chowdhury; Mohammad Umer Sharif Shohan; Kazi Injamamul Hoque; Mirza Ashikul Beg; Mohammad Ali Moni; Mohammad Kawsar Sharif Siam
Title: A Computational Approach to Design Potential siRNA Molecules as a Prospective Tool for Silencing Nucleocapsid Phosphoprotein and Surface Glycoprotein Gene of SARS-CoV-2 Document date: 2020_4_12
ID: exoc6xvt_17
Snippet: conditions. In order to decelerate the COVID-19 pandemic and recover the affected individuals the 302 development of siRNA therapeutic approaches could be a promising alternative to traditional 303 vaccine designing. into the endosomes. siRNA escape endosomes and release siRNA into the cytoplasm due to pH 510 responsive mechanism or proton sponge effect. Once generated, siRNA is loaded into RNA-indiced 511 silencing complex comprising of RNA-bind.....
Document: conditions. In order to decelerate the COVID-19 pandemic and recover the affected individuals the 302 development of siRNA therapeutic approaches could be a promising alternative to traditional 303 vaccine designing. into the endosomes. siRNA escape endosomes and release siRNA into the cytoplasm due to pH 510 responsive mechanism or proton sponge effect. Once generated, siRNA is loaded into RNA-indiced 511 silencing complex comprising of RNA-binding protein TRBP and Argonaute (AGO2 folding and free energy of binding with target. 548
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