Selected article for: "iaa modification and vivo systemic toxicity"
Author: Randall Toy; Pallab Pradhan; Vijayeetha Ramesh; Nelson C. Di Paolo; Blake Lash; Jiaying Liu; Emmeline L. Blanchard; Philip J. Santangelo; Dmitry M. Shayakhmetov; Krishnendu Roy
Title: Modification of primary amines to higher order amines reduces in vivo hematological and immunotoxicity of cationic nanocarriers through TLR4 and complement pathways
  • Document date: 2019_5_24
    • ID: cbit5xci_56
    Snippet: The primary goal of our study was to identify the principal drivers of in vivo systemic toxicity induced by two commonly studied cationic polymer nanoparticles -branched polyethylenimine and chitosan (Table 1 ) -and evaluate if and how the conversion of primary amines to tertiary amines by modification with IAA could mitigate their in vivo systemic toxicity......
    Document: The primary goal of our study was to identify the principal drivers of in vivo systemic toxicity induced by two commonly studied cationic polymer nanoparticles -branched polyethylenimine and chitosan (Table 1 ) -and evaluate if and how the conversion of primary amines to tertiary amines by modification with IAA could mitigate their in vivo systemic toxicity.

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