Author: Mehdi Baratchian; Jeff McManus; Mike Berk; Fumihiko Nakamura; Serpil Erzurum; Sanjay Mukhopadhyay; Judy Drazba; John Peterson; Ben Gaston; Nima Sharifi
Title: No evidence that androgen regulation of pulmonary TMPRSS2 explains sex-discordant COVID-19 outcomes Document date: 2020_4_21
ID: awb1stsr_8
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.21.051201 doi: bioRxiv preprint addition, AR-antagonist therapy with Enz does not suppress pulmonary TMPRSS2 expression in eugonadal male mice. Interestingly, despite similar transcript levels, we found AR protein levels are substantially higher in lungs of male mice compared with females. This finding, conditional upon validation in huma.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.04.21.051201 doi: bioRxiv preprint addition, AR-antagonist therapy with Enz does not suppress pulmonary TMPRSS2 expression in eugonadal male mice. Interestingly, despite similar transcript levels, we found AR protein levels are substantially higher in lungs of male mice compared with females. This finding, conditional upon validation in human samples, may yet help explain sex differences in COVID-19 outcomes, but likely in a manner that is independent of TMPRSS2 regulation.
Search related documents:
Co phrase search for related documents- AR antagonist and male mouse lung: 1
- female compare and sex difference: 1
- male mouse and transcript level: 1
- outcome sex difference and sex difference: 1
- protein level and sex difference: 1
- protein level and similar transcript level: 1
- protein level and transcript level: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10
- similar transcript level and transcript level: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date