Author: Sanchita Bhadra; Miguel A. Saldaña; Hannah Grace Han; Grant L. Hughes; Andrew D. Ellington
Title: Multiplex logic processing isothermal diagnostic assays for an evolving virus Document date: 2018_9_23
ID: n5liudlg_2
Snippet: To demonstrate the utility of this smart molecular diagnostic we detect both Asian and African lineage ZIKV, which can differ by as much as 12%, 29 and cleanly distinguish them from otherwise related and often co-circulating dengue virus (DENV) and chikungunya virus (CHIKV). As few as 100 ZIKV virions could be readily detected by direct analysis of artificially-infected human saliva. Pilot studies with un-infected and ZIKV-infected Aedes aegypti .....
Document: To demonstrate the utility of this smart molecular diagnostic we detect both Asian and African lineage ZIKV, which can differ by as much as 12%, 29 and cleanly distinguish them from otherwise related and often co-circulating dengue virus (DENV) and chikungunya virus (CHIKV). As few as 100 ZIKV virions could be readily detected by direct analysis of artificially-infected human saliva. Pilot studies with un-infected and ZIKV-infected Aedes aegypti mosquitoes suggest that the integrated computations performed by our smart molecular diagnostic yield results that are on par with qRT-PCR, and for the first time demonstrate 100% specificity and sensitivity in a true POC format.
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