Author: William Fitzsimmons; Robert J. Woods; John T. McCrone; Andrew Woodman; Jamie J. Arnold; Madhumita Yennawar; Richard Evans; Craig E. Cameron; Adam S. Lauring
Title: A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus Document date: 2018_4_27
ID: 8p24gszj_11
Snippet: The adaptability of WT and high fidelity viruses have generally been compared using assays 177 that measure the acquisition of drug resistance, the reversion of an attenuating point mutation, 178 or escape from microRNA in a limited number of replication cycles [5] [6] [7] 34, 36] . In these 179 experiments, mutations come at little cost, and the assays essentially quantify the beneficial 180 mutation rate. To capture better the impact of both de.....
Document: The adaptability of WT and high fidelity viruses have generally been compared using assays 177 that measure the acquisition of drug resistance, the reversion of an attenuating point mutation, 178 or escape from microRNA in a limited number of replication cycles [5] [6] [7] 34, 36] . In these 179 experiments, mutations come at little cost, and the assays essentially quantify the beneficial 180 mutation rate. To capture better the impact of both deleterious and beneficial mutations on 8 adaptability, we measured the fitness gain of WT and 3D G64S over twenty passages in HeLa.
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