Author: Liao, Mingfeng; Liu, Yang; Yuan, Jing; Wen, Yanling; Xu, Gang; Zhao, Juanjuan; Cheng, Lin; Li, Jinxiu; Wang, Xin; Wang, Fuxiang; Liu, Lei; Amit, Ido; Zhang, Shuye; Zhang, Zheng
Title: Single-cell landscape of bronchoalveolar immune cells in patients with COVID-19. Cord-id: by82en6k Document date: 2020_5_12
ID: by82en6k
Snippet: Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+
Document: Respiratory immune characteristics associated with Coronavirus Disease 2019 (COVID-19) severity are currently unclear. We characterized bronchoalveolar lavage fluid immune cells from patients with varying severity of COVID-19 and from healthy people by using single-cell RNA sequencing. Proinflammatory monocyte-derived macrophages were abundant in the bronchoalveolar lavage fluid from patients with severe COVID-9. Moderate cases were characterized by the presence of highly clonally expanded CD8+ T cells. This atlas of the bronchoalveolar immune microenvironment suggests potential mechanisms underlying pathogenesis and recovery in COVID-19.
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