Author: William Fitzsimmons; Robert J. Woods; John T. McCrone; Andrew Woodman; Jamie J. Arnold; Madhumita Yennawar; Richard Evans; Craig E. Cameron; Adam S. Lauring
Title: A speed-fidelity trade-off determines the mutation rate and virulence of an RNA virus Document date: 2018_4_27
ID: 8p24gszj_29
Snippet: We used a well-studied antimutator variant of poliovirus to identify the selective forces that 248 optimize a pathogen's mutation rate. Using three different assays, we identified a significant 249 fitness cost to higher fidelity and directly link this cost to viral replication kinetics. Our 250 quantitative model of the speed-fidelity trade-off suggests that selection for replicative speed 251 has pushed viral mutation rates to a level that impo.....
Document: We used a well-studied antimutator variant of poliovirus to identify the selective forces that 248 optimize a pathogen's mutation rate. Using three different assays, we identified a significant 249 fitness cost to higher fidelity and directly link this cost to viral replication kinetics. Our 250 quantitative model of the speed-fidelity trade-off suggests that selection for replicative speed 251 has pushed viral mutation rates to a level that imposes a significant fitness cost at baseline due 252 to lethal or highly deleterious mutations. Consistent with the trade-off model, direct selection for 253 increased replicative speed led to indirect selection of polymerases with higher mutation rates.
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