Benzothiazoles as potential antiviral agents

Asiri, Yahya I.; Alsayari, Abdulrhman; Muhsinah, Abdullatif B.; Mabkhot, Yahia N.; Hassan, Mohd. Z.

OBJECTIVES: The recent viral pandemic poses a unique challenge for healthcare providers. Despite the remarkable progress, the number of novel antiviral agents in the pipeline is woefully inadequate against the evolving virulence and drug resistance of current viruses. This highlights the urgent need for new and improved vaccines, diagnostics and therapeutic agents to obviate the viral pandemic. KEY FINDINGS: Benzothiazole plays a pivotal role in the design and development of antiviral drugs. This is evident from the fact that it comprises many clinically useful agents. The current review is aimed to provide an insight into the recent development of benzothiazole‐based antiviral agents, with a special focus on their structure‐activity relationships and lead optimisation. One hundred and five articles were initially identified, and from these studies, 64 potential novel lead molecules and main findings were highlighted in this review. SUMMARY: We hope this review will provide a logical perspective on the importance of improving the future designs of novel broad‐spectrum benzothiazole‐based antiviral agents to be used against emerging viral diseases.