Selected article for: "essential polymerase cofactor and polymerase cofactor"
Author: MJ Morwitzer; A Corona; L Zinzula; E Fanunza; C Nigri; S Distinto; C Vornholt; V Kumar; E Tramontano; SP Reid
Title: Mutation of Ebola virus VP35 Ser129 uncouples interferon antagonist and replication functions
  • Document date: 2019_8_7
    • ID: cbyzdnrp_7
    Snippet: protein and providing a potentially valuable therapeutic target. suppression, VP35 also functions as an essential cofactor of the viral RNA-dependent RNA 82 polymerase (named L for large polymerase protein). The functional viral polymerase complex is 83 comprised of nucleoprotein (NP) and VP30 in addition to L and VP35 (Muhlberger et (1976 Yambuku-Mayinga strain) was constructed as previously reported (Cannas et al., 2015) ......
    Document: protein and providing a potentially valuable therapeutic target. suppression, VP35 also functions as an essential cofactor of the viral RNA-dependent RNA 82 polymerase (named L for large polymerase protein). The functional viral polymerase complex is 83 comprised of nucleoprotein (NP) and VP30 in addition to L and VP35 (Muhlberger et (1976 Yambuku-Mayinga strain) was constructed as previously reported (Cannas et al., 2015) .

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