Selected article for: "early response and high sensitivity"
Author: Wanbing Liu; Lei Liu; Guomei Kou; Yaqiong Zheng; Yinjuan Ding; Wenxu Ni; Qiongshu Wang; Li Tan; Wanlei Wu; Shi Tang; Zhou Xiong; Shangen Zheng
Title: Evaluation of Nucleocapsid and Spike Protein-based ELISAs for detecting antibodies against SARS-CoV-2
  • Document date: 2020_3_20
    • ID: lm9pay2b_26
    Snippet: In this study, we evaluated immunoassays for the detection of antibodies against 223 SARS-CoV-2. Specifically, we evaluated IgM and IgG production and their diagnostic 224 value. rN-and rS-based ELISAs were used to detect IgM and IgG in serum samples 225 of confirmed COVID-19 patients. The results revealed that the rS-based ELISA is 226 more sensitive than the rN-based one in the detection of IgM antibodies (Fig. 1) . We 227 speculate that this d.....
    Document: In this study, we evaluated immunoassays for the detection of antibodies against 223 SARS-CoV-2. Specifically, we evaluated IgM and IgG production and their diagnostic 224 value. rN-and rS-based ELISAs were used to detect IgM and IgG in serum samples 225 of confirmed COVID-19 patients. The results revealed that the rS-based ELISA is 226 more sensitive than the rN-based one in the detection of IgM antibodies (Fig. 1) . We 227 speculate that this difference is due to the relatively high sensitivity and early 228 response to the S antigen compared to the N antigen in patients with COVID-19. We is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.

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