Selected article for: "immune response and significant effect"
Author: Auray, Gaël; Lachance, Claude; Wang, Yingchao; Gagnon, Carl A.; Segura, Mariela; Gottschalk, Marcelo
Title: Transcriptional Analysis of PRRSV-Infected Porcine Dendritic Cell Response to Streptococcus suis Infection Reveals Up-Regulation of Inflammatory-Related Genes Expression
  • Cord-id: kx7z79pf
  • Document date: 2016_5_23
    • ID: kx7z79pf
    Snippet: The porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important swine pathogens and often serves as an entry door for other viral or bacterial pathogens, of which Streptococcus suis is one of the most common. Pre-infection with PRRSV leads to exacerbated disease caused by S. suis infection. Very few studies have assessed the immunological mechanisms underlying this higher susceptibility. Since antigen presenting cells play a major role in the initiation of the immune
    Document: The porcine reproductive and respiratory syndrome virus (PRRSV) is one of the most important swine pathogens and often serves as an entry door for other viral or bacterial pathogens, of which Streptococcus suis is one of the most common. Pre-infection with PRRSV leads to exacerbated disease caused by S. suis infection. Very few studies have assessed the immunological mechanisms underlying this higher susceptibility. Since antigen presenting cells play a major role in the initiation of the immune response, the in vitro transcriptional response of bone marrow-derived dendritic cells (BMDCs) and monocytes in the context of PRRSV and S. suis co-infection was investigated. BMDCs were found to be more permissive than monocytes to PRRSV infection; S. suis phagocytosis by PRRSV-infected BMDCs was found to be impaired, whereas no effect was found on bacterial intracellular survival. Transcription profile analysis, with a major focus on inflammatory genes, following S. suis infection, with and without pre-infection with PRRSV, was then performed. While PRRSV pre-infection had little effect on monocytes response to S. suis infection, a significant expression of several pro-inflammatory molecules was observed in BMDCs pre-infected with PRRSV after a subsequent infection with S. suis. While an additive effect could be observed for CCL4, CCL14, CCL20, and IL-15, a distinct synergistic up-regulatory effect was observed for IL-6, CCL5 and TNF-α after co-infection. This increased pro-inflammatory response by DCs could participate in the exacerbation of the disease observed during PRRSV and S. suis co-infection.

    Search related documents:
    Co phrase search for related documents
    • absence presence and activation profile: 1
    • absence presence and acute disease: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17
    • absence presence and acute phase: 1, 2, 3, 4, 5, 6, 7, 8
    • absence presence and additional file: 1, 2, 3, 4, 5, 6, 7
    • absence presence and low bacterial: 1
    • accession number and acute phase: 1
    • accession number and additional file: 1
    • activated cell and acute disease: 1, 2, 3, 4, 5, 6, 7
    • activated cell and acute phase: 1, 2, 3, 4, 5
    • activation profile and acute disease: 1, 2, 3
    • activation profile and acute phase: 1
    • activation stimulus and acute disease: 1
    • acute disease and additional file: 1, 2, 3, 4, 5, 6, 7, 8
    • acute disease and additive effect: 1, 2
    • acute disease and long incubation time: 1, 2, 3, 4
    • acute disease and low bacterial: 1, 2, 3, 4, 5
    • acute phase and additive effect: 1
    • acute phase and low bacterial: 1