Author: Pingping Zhang; Qi Gao; Tang Wang; Yuehua Ke; Fei Mo; Ruizhong Jia; Wanbing Liu; Lei Liu; Shangen Zheng; Yuzhen Liu; Luping Li; Yao Wang; Lei Xu; Kun Hao; Ruifu Yang; Shiyue Li; Changqing Lin; Yong Zhao
Title: Evaluation of recombinant nucleocapsid and spike proteins for serological diagnosis of novel coronavirus disease 2019 (COVID-19) Document date: 2020_3_20
ID: 7atoko6c_4
Snippet: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.17.20036954 doi: medRxiv preprint 5 spike protein (S protein), envelope protein (E), membrane protein (M), and 1 nucleocapsid protein (N protein). Among them, the N-protein is the most abundant, 2 relatively conservative protein in coronaviruses; thus, it is often used as a diagnostic 3 antigen [7] . Our previous study showed that the ant.....
Document: The copyright holder for this preprint (which was not peer-reviewed) is the . https://doi.org/10.1101/2020.03.17.20036954 doi: medRxiv preprint 5 spike protein (S protein), envelope protein (E), membrane protein (M), and 1 nucleocapsid protein (N protein). Among them, the N-protein is the most abundant, 2 relatively conservative protein in coronaviruses; thus, it is often used as a diagnostic 3 antigen [7] . Our previous study showed that the antigenicity of the COOH terminus is 4 higher than that of the NH 2 terminus in the SARS-CoV N protein, and that the former 5 N protein fragment may have the same antigenicity as that seen with the full-length N 6 protein [8] . In contrast, the S protein is the common target when designing vaccines 7 based on neutralizing antibodies. It contains a receptor binding domain (S-RBD) in 8 the S1 subunit, which mediates receptor binding and membrane fusion [9, 10]. 9
Search related documents:
Co phrase search for related documents- bind domain and fusion membrane receptor binding: 1
- bind domain and fusion membrane receptor binding mediate: 1
- bind domain and membrane protein: 1, 2, 3, 4, 5, 6
- bind domain and membrane receptor binding: 1
- bind domain and neutralize antibody: 1, 2
- bind domain and previous study: 1, 2
- bind domain and receptor bind domain: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- bind domain and receptor binding: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60, 61, 62, 63, 64, 65, 66, 67, 68, 69, 70, 71, 72, 73
- bind domain and S1 subunit: 1, 2, 3, 4, 5
- bind domain and spike protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51, 52, 53, 54, 55, 56, 57, 58, 59, 60
- common target and envelope protein: 1
- common target and fusion membrane receptor binding: 1
- common target and membrane protein: 1
- common target and membrane receptor binding: 1
- common target and previous study: 1
- common target and receptor binding: 1, 2, 3, 4, 5, 6, 7
- common target and spike protein: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11
- COOH terminus and membrane protein: 1, 2, 3, 4, 5, 6, 7, 8, 9
- COOH terminus and previous study: 1
Co phrase search for related documents, hyperlinks ordered by date