Author: Hughes, Carly M.; Gregory, Gareth P.; Pierce, Anna B.; Druce, Julian D.; Catton, Mike; Chong, Brian; Sherry, Norelle L.; Graham, Maryza; Chen, Melissa; Salvaris, Ross; Eise, Nicole; Lee, Jean Y.H.; McQuilten, Zoe; Crouch, Simon; Looker, Clare; Korman, Tony M.; Stuart, Rhonda L.
Title: Clinical illness with viable severe acute respiratory coronavirus virus 2 (SARS-CoV-2) virus presenting 72 days after infection in an immunocompromised patient Cord-id: kuyrelpe Document date: 2021_3_19
ID: kuyrelpe
Snippet: We present a case of late symptom onset of COVID-19 infection 72 days after initial diagnosis in an immunocompromised 53-year-old man. SARS-CoV-2 was cultured from his sputum sample at this time, and genomic sequencing suggested reinfection was unlikely. After receipt of convalescent plasma, SARS-CoV-2 became undetectable by PCR 111 days after diagnosis, although SARS-CoV-2 antibodies remained not detectable. This case posed difficult public health management issues in a low prevalence COVID-19
Document: We present a case of late symptom onset of COVID-19 infection 72 days after initial diagnosis in an immunocompromised 53-year-old man. SARS-CoV-2 was cultured from his sputum sample at this time, and genomic sequencing suggested reinfection was unlikely. After receipt of convalescent plasma, SARS-CoV-2 became undetectable by PCR 111 days after diagnosis, although SARS-CoV-2 antibodies remained not detectable. This case posed difficult public health management issues in a low prevalence COVID-19 setting as the person required extended home isolation given his prolonged SARS-CoV-2 PCR detection.
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