Evaluations of serological test in the diagnosis of 2019 novel coronavirus (SARS-CoV-2) infections during the COVID-19 outbreak

Dachuan Lin; Lei Liu; Mingxia Zhang; Yunlong Hu; Qianting Yang; Jiubiao Guo; Youchao Dai; Yuzhong Xu; Yi Cai; Xinchun Chen; Kaisong Huang; Zheng Zhang

is the (which was not peer-reviewed) The copyright holder for this preprint . https: //doi.org/10.1101 //doi.org/10. /2020 To explore whether the onset time was significantly linked with the detection sensitivity by this 165 serological chemiluminescence method, comparison and statistical analysis of the sensitivity rates 166 between different onset time patient categories was undertaken. No statistically significant 167 difference was observed between the IgM and IgG testing results in the patients with the same onset 168 time, although two more cases from 12 cases were detected by IgM testing compared to that of IgG 169 testing in patients less than the one-week onset of disease (Table 2 , p-value ˃0.05). In stark contrast, 170 two more cases SARS-CoV-2 patients were identified by IgG testing than that of IgM testing in patients 171 with more than two weeks onset of disease (p-value ˃0.05). In addition, we also compared the 172 detection rates between the different age groups people, and we found that a significantly lower 173 detection rate in both lgM and lgG testing manner for individual group younger than 18 years old was 174 observed compared to that of people aging from 18 to 65 (p-value < 0.01) or over 65 years old (p-175 value ˃0.05) (Supplementary Table S1 ). No statistically significant differences were observed for male 176 and female groups as well. CC-BY-NC 4.0 International license It is made available under a author/funder, who has granted medRxiv a license to display the preprint in perpetuity.