Author: Nathan R Tucker; Mark Chaffin; Kenneth C Bedi; Irinna Papangeli; Amer-Denis Akkad; Alessandro Arduini; Sikander Hayat; Gökcen Eraslan; Christoph Muus; Roby Bhattacharyya; Christian M Stegmann; Kenneth B Margulies; Patrick T Ellinor
Title: Myocyte Specific Upregulation of ACE2 in Cardiovascular Disease: Implications for SARS-CoV-2 mediated myocarditis Document date: 2020_4_14
ID: bh21hj5l_1
Snippet: converting enzyme 2 (ACE2) receptor. 1 Hypertension and pre-existing cardiovascular disease are risk factors for morbidity from COVID-19, 2 and it remains uncertain whether the use of angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB) impacts infection and disease. Here, we aim to shed light on this question by assessing ACE2 expression in normal and diseased human myocardial samples profiled by bulk and single.....
Document: converting enzyme 2 (ACE2) receptor. 1 Hypertension and pre-existing cardiovascular disease are risk factors for morbidity from COVID-19, 2 and it remains uncertain whether the use of angiotensin converting enzyme inhibitors (ACEi) or angiotensin receptor blockers (ARB) impacts infection and disease. Here, we aim to shed light on this question by assessing ACE2 expression in normal and diseased human myocardial samples profiled by bulk and single nucleus RNA-seq.
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