Author: Hardy, Michael; Douxfils, Jonathan; Bareille, Marion; Lessire, Sarah; Gouinâ€Thibault, Isabelle; Fontana, Pierre; Lecompte, Thomas; Mullier, François
Title: Studies on hemostasis in COVIDâ€19 deserve careful reporting of the laboratory methods, their significance and their limitations Cord-id: ecg1ao5y Document date: 2020_8_13
ID: ecg1ao5y
Snippet: We read with much interest the recent observational study of Nougier et al., which aimed at studying thrombin generation (TG) and fibrinolysis profiles of COVIDâ€19 patients admitted to an intensive care unit (ICU) or to an internal medicine ward and receiving various schemes of prophylactic heparin.[1] They reported that thrombin potential remained within normal range despite heparin and that fibrinolysis was decreased in relation with increased plasminogen activator inhibitor 1 (PAIâ€1) and
Document: We read with much interest the recent observational study of Nougier et al., which aimed at studying thrombin generation (TG) and fibrinolysis profiles of COVIDâ€19 patients admitted to an intensive care unit (ICU) or to an internal medicine ward and receiving various schemes of prophylactic heparin.[1] They reported that thrombin potential remained within normal range despite heparin and that fibrinolysis was decreased in relation with increased plasminogen activator inhibitor 1 (PAIâ€1) and thrombinâ€activatable fibrinolysis inhibitor (TAFI) antigen plasma levels. Using the rotational thromboelastometry (ROTEM) delta device with EXTEM reagents and the addition of 0.625µg/mL tPA (referred to as ‘TEMâ€tPA’), they reported decreased clot lysis in COVIDâ€19 patients, which was more pronounced in patients who presented a thrombotic event, compared to eventâ€free patients.
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