Risk factors for the COVID‐19 severity and its correlation with viral shedding: A retrospective cohort study

Zheng, Xinchun; Chen, Jiehua; Deng, Lisi; Fang, Zhaoxiong; Chen, Gongqi; Ye, Di; Xia, Jinyu; Hong, Zhongsi

Coronavirus disease 2019 (COVID‐19) have become a pandemic in the world. This study is aim to explore risk factors for COVID‐19 severity in the early stage and the correlation between the viral shedding and COVID‐19 severity. We included inpatient with laboratory confirmed COVID‐19 who had been discharged by 9 March 2020. The medical record data and dynamic change of biochemical indicators in‐hospital were compared between common and severe patients. Eighty patients were included in this study. Multivariable regression demonstrated increasing odds of severity associated with the duration of fever (odds ratio [OR], 1.42; 95% confidence interval [CI], 1.10‐1.82, per day increase; P = .007), C‐reactive protein (CRP) (OR, 1.26; 95% CI, 1.04‐1.52; P = .02), and PO(2) < 80 mm Hg (28.07, 95% CI, 1.50‐524.12; P = .026) on admission. We found severe acute respiratory syndrome coronavirus 2 viral RNA could be long‐term presence in respiratory tract and fecal sample, up to 43 and 46 days, respectively. However, the duration of viral shedding have no correlation with the COVID‐19 severity. The duration of fever, elevated CRP and PO(2) < 80 mm Hg on admission were associated with the COVID‐19 severity in the early stage and there is no correlation between the viral shedding and COVID‐19 severity.