Author: Wu Liu; Mehmet U. Caglar; Zhangming Mao; Andrew Woodman; Jamie J. Arnold; Claus O. Wilke; Craig E. Cameron
Title: More than efficacy revealed by single-cell analysis of antiviral therapeutics Document date: 2019_4_12
ID: aiyg061l_7
Snippet: A device for single-cell analysis of the activity of antiviral agents. Our initial foray into 65 single-cell analysis of PV infection dynamics used cell density to control single-cell occupancy 66 of wells of a microfluidic device (Guo et al., 2017) . What this means practically is that most 67 wells are empty. Reducing the number of events monitored by a mere factor of two takes us 68 below the number of events required for statistical analysis .....
Document: A device for single-cell analysis of the activity of antiviral agents. Our initial foray into 65 single-cell analysis of PV infection dynamics used cell density to control single-cell occupancy 66 of wells of a microfluidic device (Guo et al., 2017) . What this means practically is that most 67 wells are empty. Reducing the number of events monitored by a mere factor of two takes us 68 below the number of events required for statistical analysis of the data. Acquisition of a dose-69 response curve was therefore impossible using this first-generation device. 70
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