Selected article for: "spike protein and trimeric spike"

Author: Craig Thompson; Nicholas Grayson; Robert Paton; José Lourenço; Bridget Penman; Lian Ni Lee; Valerie Odon; Juthathip Mongkolsapaya; Senthil Chinnakannan; Wanwisa Dejnirattisai; Matthew Edmans; Alexander Fyfe; Carol Imlach; Kreepa Kooblall; Nicholas Lim; Chang Liu; Cesar Lopez-Camacho; Carol-Anne McInally; Narayan Ramamurthy; Jeremy Ratcliff; Piyada Supasa; Beibei Wang; Alexander J Mentzer; Marc Turner; Calum Semple; John Kenneth Baillie; Heli Harvala; Gavin Screaton; Nigel Temperton; Paul Klenerman; Lisa Jarvis; Sunetra Gupta; Peter Simmonds
Title: Neutralising antibodies to SARS coronavirus 2 in Scottish blood donors - a pilot study of the value of serology to determine population exposure
  • Document date: 2020_4_17
  • ID: nm2bq717_8
    Snippet: StrepMAB-Classic (2-1507-001;iba). Plates were blocked with 2% skimmed milk in PBS for one hour and then incubated with 0.125ug of soluble trimeric SARS-CoV2 trimeric Spike protein or 2% skimmed milk in PBS. After one hour, plasma was added at 1:50 dilution, followed by ALP-conjugated anti-human IgG (A9544; Sigma) at 1:10,000 dilution or ALPconjugated anti-human IgM (A9794; Sigma) at 1:5,000 dilution. The reaction was developed 150 by the additio.....
    Document: StrepMAB-Classic (2-1507-001;iba). Plates were blocked with 2% skimmed milk in PBS for one hour and then incubated with 0.125ug of soluble trimeric SARS-CoV2 trimeric Spike protein or 2% skimmed milk in PBS. After one hour, plasma was added at 1:50 dilution, followed by ALP-conjugated anti-human IgG (A9544; Sigma) at 1:10,000 dilution or ALPconjugated anti-human IgM (A9794; Sigma) at 1:5,000 dilution. The reaction was developed 150 by the addition of PNPP substrate and stopped with NaOH. The absorbance was measured at 405nm after 1 hour.

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