Author: Myra Hosmillo; Jia Lu; Michael R. McAllaster; James B. Eaglesham; Xinjie Wang; Edward Emmott; Patricia Domingues; Yasmin Chaudhry; Timothy J Fitzmaurice; Matthew K.H. Tung; Marc Panas; Gerald McInerney; Nicholas Locker; Craig B. Willen; Ian Goodfellow
Title: Noroviruses subvert the core stress granule component G3BP1 to promote viral VPg-dependent translation Document date: 2019_3_8
ID: d0q5lhf4_19
Snippet: To confirm the role of G3BP1 in the norovirus life cycle we examined the ability of full 235 length and truncated versions of G3BP1 to restore norovirus replication in G3BP1 236 knockout cells. A mouse BV-2 G3BP1 knockout cell line was complemented with 237 either full length G3BP1 or variants lacking the RGG or both the RGG and RRM 238 binding domains ( Fig 6A) and the impact on viral replication assessed. 239.....
Document: To confirm the role of G3BP1 in the norovirus life cycle we examined the ability of full 235 length and truncated versions of G3BP1 to restore norovirus replication in G3BP1 236 knockout cells. A mouse BV-2 G3BP1 knockout cell line was complemented with 237 either full length G3BP1 or variants lacking the RGG or both the RGG and RRM 238 binding domains ( Fig 6A) and the impact on viral replication assessed. 239
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