Author: Zarandi, Peyman Kheirandish; Zinatizadeh, Mohammad Reza; Zinatizadeh, Maryam; Yousefi, Mohammad Hadi; Rezaei, Nima
Title: SARS-CoV-2: From the pathogenesis to potential anti-viral treatments Cord-id: fc5tmt70 Document date: 2021_2_2
ID: fc5tmt70
Snippet: INTRODUCTION: The world is witnessing the spread of one of the members of Coronaviruses (CoVs) family, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the 21st century. Considering the short time spent after its prevalence, limited information is known about the effect of the virus mechanism on different organs of the body; meanwhile the lack of specific treatment and vaccine for this virus has exposed millions of people to a big challenge. AREAS COVERED: The review articl
Document: INTRODUCTION: The world is witnessing the spread of one of the members of Coronaviruses (CoVs) family, called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the 21st century. Considering the short time spent after its prevalence, limited information is known about the effect of the virus mechanism on different organs of the body; meanwhile the lack of specific treatment and vaccine for this virus has exposed millions of people to a big challenge. AREAS COVERED: The review article aims to describe the general and particular characteristics of CoVs, their classification, genome structure, host cell infection, cytokine storm, anti-viral treatments, and inhibition of COVID-19-related ER-mitochondrial stress. In addition, it refers to drugs such as Chloroquine/Hydroxychloroquine, Lopinavir/Ritonavir, darunavir, ribavirin, remdesivir, and favipiravir, which have undergone clinical trials for coronavirus disease 2019 (COVID-19) treatment. This analysis was derived from an extensive scientific literature search including Pubmed, ScienceDirect, and Google Scholar performed. EXPERT OPINION: The effectiveness rate and complications of these drugs can reveal new insights into the potential therapeutic goals for the disease. Moreover, lifestyle change can effectively prevent SARS-CoV-2 infection.
Search related documents:
Co phrase search for related documents- abdominal pain and liver cell: 1
- abdominal pain and liver cell intestine: 1
- abdominal pain and lopinavir ritonavir: 1, 2, 3, 4
- abdominal pain vomiting and acute ards respiratory distress syndrome: 1
- abdominal pain vomiting and liver cell: 1
- abdominal pain vomiting and liver cell intestine: 1
- abdominal pain vomiting and lopinavir ritonavir: 1, 2, 3
- abdominal pain vomiting diarrhea and liver cell: 1
- abdominal pain vomiting diarrhea and liver cell intestine: 1
- abdominal pain vomiting diarrhea and lopinavir ritonavir: 1, 2
- activate protein and acute ards respiratory distress syndrome: 1
- activate protein and adaptive innate: 1, 2, 3
- activate protein and lopinavir ritonavir: 1
- acute ards respiratory distress syndrome and adaptive innate: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22
- acute ards respiratory distress syndrome and adaptive innate immune response: 1, 2, 3, 4, 5, 6, 7
- acute ards respiratory distress syndrome and liver cell: 1, 2
- acute ards respiratory distress syndrome and lopinavir ritonavir: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25
- adaptive innate and liver cell: 1, 2, 3
- adaptive innate and lopinavir ritonavir: 1, 2, 3
Co phrase search for related documents, hyperlinks ordered by date