Author: Singh, Ramandeep; Kang, Alisha; Luo, Xiangqian; Jeyanathan, Mangalakumari; Gillgrass, Amy; Afkhami, Sam; Xing, Zhou
Title: COVIDâ€19: Current knowledge in clinical features, immunological responses, and vaccine development Cord-id: i6f2634a Document date: 2021_2_12
ID: i6f2634a
Snippet: The COVIDâ€19 pandemic has unfolded to be the most challenging global health crisis in a century. In 11 months since its first emergence, according to WHO, the causative infectious agent SARSâ€CoVâ€2 has infected more than 100 million people and claimed more than 2.15 million lives worldwide. Moreover, the world has raced to understand the virus and natural immunity and to develop vaccines. Thus, within a short 11 months a number of highly promising COVIDâ€19 vaccines were developed at an un
Document: The COVIDâ€19 pandemic has unfolded to be the most challenging global health crisis in a century. In 11 months since its first emergence, according to WHO, the causative infectious agent SARSâ€CoVâ€2 has infected more than 100 million people and claimed more than 2.15 million lives worldwide. Moreover, the world has raced to understand the virus and natural immunity and to develop vaccines. Thus, within a short 11 months a number of highly promising COVIDâ€19 vaccines were developed at an unprecedented speed and are now being deployed via emergency use authorization for immunization. Although a considerable number of review contributions are being published, all of them attempt to capture only a specific aspect of COVIDâ€19 or its therapeutic approaches based on everâ€expanding information. Here, we provide a comprehensive overview to conceptually thread together the latest information on global epidemiology and mitigation strategies, clinical features, viral pathogenesis and immune responses, and the current state of vaccine development.
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