Author: Monika Abedin Sigg; Tabea Menchen; Jeffery Johnson; Chanjae Lee; Semil P. Choksi; Galo Garcia; Henriette Busengdal; Gerard Dougherty; Petra Pennekamp; Claudius Werner; Fabian Rentzsch; Nevan Krogan; John B. Wallingford; Heymut Omran; Jeremy F. Reiter
Title: Evolutionary proteomics uncovers ciliary signaling components Document date: 2017_6_22
ID: 9y8r277c_19
Snippet: and not to primary cilia. To test this hypothesis, we determined whether proteins that did not 280 localize to IMCD3 primary cilia can localize to the motile cilia of the zebrafish Kupffer's 281 vesicle. CCDC37 (CFAP100) and PIN1, two proteins that did not localize to primary cilia in 282 IMCD3 cells, localized to motile cilia of the zebrafish embryo ( Figure 3D and S1C). Unlike 283 CCDC37, PIN1 localized to some, but not all primary cilia in the.....
Document: and not to primary cilia. To test this hypothesis, we determined whether proteins that did not 280 localize to IMCD3 primary cilia can localize to the motile cilia of the zebrafish Kupffer's 281 vesicle. CCDC37 (CFAP100) and PIN1, two proteins that did not localize to primary cilia in 282 IMCD3 cells, localized to motile cilia of the zebrafish embryo ( Figure 3D and S1C). Unlike 283 CCDC37, PIN1 localized to some, but not all primary cilia in the zebrafish embryo. Conversely, 284 CCDC170 localized to the base of primary cilia in IMCD3 cells and in the zebrafish embryo, but 285 did not localize to the motile cilia of Kupffer's vesicle. These data reveal that some proteins 286 localize specifically to either motile or primary cilia. 287 288
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