“Mass gathering events and COVID-19 transmission in Borriana (Spain): A retrospective cohort study”

Domènech-Montoliu, Salvador; Pac-Sa, Maria Rosario; Vidal-Utrillas, Paula; Latorre-Poveda, Marta; Del Rio-González, Alba; Ferrando-Rubert, Sara; Ferrer-Abad, Gema; Sánchez-Urbano, Manuel; Aparisi-Esteve, Laura; Badenes-Marques, Gema; Cervera-Ferrer, Belén; Clerig-Arnau, Ursula; Dols-Bernad, Claudia; Fontal-Carcel, Maria; Gomez-Lanas, Lorna; Jovani-Sales, David; León-Domingo, Maria Carmen; Llopico-Vilanova, Maria Dolores; Moros-Blasco, Mercedes; Notari-Rodríguez, Cristina; Ruíz-Puig, Raquel; Valls-López, Sonia; Arnedo-Pena, Alberto

OBJECTIVE: Mass gathering events (MGEs) are associated with the transmission of COVID-19. Between 6 and 10 March 2020, several MGEs related to the Falles festival took place in Borriana, a municipality in the province of Castellon (Spain). The aim of this study was to estimate the incidence of COVID-19 and its association with these MGEs, and to quantify the potential risk factors of its occurrence. METHODS: During May and June 2020, a population-based retrospective cohort study was carried out by the Public Health Center of Castelló and the Hospital de la Plana in Vila-real. Participants were obtained from a representative sample of 1663 people with potential exposure at six MGEs. A questionnaire survey was carried out to obtain information about attendance at MGEs and COVID-19 disease. In addition, a serologic survey of antibodies against SARS-Cov-2 was implemented. Inverse probability weighted regression was used in the statistical analysis. RESULTS: A total of 1338 subjects participated in the questionnaire survey (80.5%), 997 of whom undertook the serologic survey. Five hundred and seventy cases were observed with an attack rate (AR) of 42.6%; average age was 36 years, 62.3% were female, 536 cases were confirmed by laboratory tests, and 514 cases were found with SARS-CoV-2 total antibodies. Considering MGE exposure, AR was 39.2% (496/1264). A dose-response relationship was found between MGE attendance and the disease, (adjusted relative risk [aRR] = 4.11 95% confidence interval [CI]3.25–5.19). Two MGEs with a dinner and dance in the same building had higher risks. Associated risk factors with the incidence were older age, obesity, and upper and middle class versus lower class; current smoking was protective. CONCLUSIONS: The study suggests the significance of MGEs in the COVID-19 transmission that could explain the subsequent outbreak in Borriana.