Author: Vita, Serena; Di Bari, Virginia; Corpolongo, Angela; Goletti, Delia; Espinosa, Joaquin; Petracca, Sebastiano; Palmieri, Fabrizio; Nicastri, Emanuele
Title: Down Syndrome patients with COVID-19 pneumonia: a high-risk category for unfavourable outcome Cord-id: g30eoo8l Document date: 2020_11_30
ID: g30eoo8l
Snippet: We report two cases of COronaVIrus Disease-19 in patients with Down Syndrome and describe the identification, diagnosis, clinical course, and management of the infection. Down Syndrome, which is caused by trisomy 21, is characterized by immune dysregulation, anatomical differences in the upper respiratory tract, and higher rate of comorbidities. All these risk factors can contribute to more severe clinical presentations of COVID-19. It is essential to raise awareness of the clinical relevance of
Document: We report two cases of COronaVIrus Disease-19 in patients with Down Syndrome and describe the identification, diagnosis, clinical course, and management of the infection. Down Syndrome, which is caused by trisomy 21, is characterized by immune dysregulation, anatomical differences in the upper respiratory tract, and higher rate of comorbidities. All these risk factors can contribute to more severe clinical presentations of COVID-19. It is essential to raise awareness of the clinical relevance of SARS-COV-2 infection in DS patients, as well in other most vulnerable patients in order to improve their management and treatment and to candidate these individuals for vaccination, once available.
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