Author: Aran Singanayagam; Joseph Footitt; Benjamin T Kasdorf; Matthias Marczynski; Michael T Cross; Lydia J Finney; Maria-Belen Trujillo Torralbo; Maria Calderazzo; Jie Zhu; Julia Aniscenko; Thomas B Clarke; Philip L Molyneaux; Nathan W Bartlett; Miriam F Moffatt; William O Cookson; Jadwiga Wedzicha; Christopher M Evans; Oliver Lieleg; Patrick Mallia; Sebastian L Johnston
Title: MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation Document date: 2019_7_22
ID: gg2ctmn7_2
Snippet: Respiratory mucosal surfaces are continuously exposed to inhaled pathogens and a protective layer of secreted mucus that is rich in mucin glycoproteins acts as a first-line of defense against infection. Alterations in mucus secretion including enhancement of the major airway mucins MUC5AC and MUC5B are a cardinal feature of inflammatory airway COPD [5] [6] [7] . The complexity of interactions between mucins and pathogens and how the perturbations.....
Document: Respiratory mucosal surfaces are continuously exposed to inhaled pathogens and a protective layer of secreted mucus that is rich in mucin glycoproteins acts as a first-line of defense against infection. Alterations in mucus secretion including enhancement of the major airway mucins MUC5AC and MUC5B are a cardinal feature of inflammatory airway COPD [5] [6] [7] . The complexity of interactions between mucins and pathogens and how the perturbations in mucin expression that occur in COPD affect infection susceptibility and subsequent exacerbation pathogenesis are poorly understood and it is not known whether inhibition of mucus production would be beneficial or harmful in this context.
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