Selected article for: "bacterial infection and negative correlation"
Author: Aran Singanayagam; Joseph Footitt; Benjamin T Kasdorf; Matthias Marczynski; Michael T Cross; Lydia J Finney; Maria-Belen Trujillo Torralbo; Maria Calderazzo; Jie Zhu; Julia Aniscenko; Thomas B Clarke; Philip L Molyneaux; Nathan W Bartlett; Miriam F Moffatt; William O Cookson; Jadwiga Wedzicha; Christopher M Evans; Oliver Lieleg; Patrick Mallia; Sebastian L Johnston
Title: MUC5AC drives COPD exacerbation severity through amplification of virus-induced airway inflammation
  • Document date: 2019_7_22
    • ID: gg2ctmn7_46
    Snippet: We have previously reported that experimental RV infection in patients with COPD is associated with increased frequency of secondary bacterial infection compared to healthy subjects 16,26 via a mechanism of virus-induced neutrophil elastase-mediated cleavage of the anti-microbial peptides SLPI and elafin. The positive correlation of sputum MUC5AC with neutrophil numbers, neutrophil elastase concentrations and secondary bacterial infection and neg.....
    Document: We have previously reported that experimental RV infection in patients with COPD is associated with increased frequency of secondary bacterial infection compared to healthy subjects 16,26 via a mechanism of virus-induced neutrophil elastase-mediated cleavage of the anti-microbial peptides SLPI and elafin. The positive correlation of sputum MUC5AC with neutrophil numbers, neutrophil elastase concentrations and secondary bacterial infection and negative correlation with SLPI and elafin levels observed in the current study suggests that increased MUC5AC could be one mechanism contributing to enhanced neutrophilic author/funder. All rights reserved. No reuse allowed without permission.

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