Author: Beddingfield, Brandon J.; Iwanaga, Naoki; Chapagain, Prem P.; Zheng, Wenshu; Roy, Chad J.; Hu, Tony Y.; Kolls, Jay K.; Bix, Gregory J.
Title: The Integrin Binding Peptide, ATN-161, as a Novel Therapy for SARS-CoV-2 Infection Cord-id: gstxmrn4 Document date: 2020_10_16
ID: gstxmrn4
Snippet: Many efforts to design and screen therapeutics for the current severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic have focused on inhibiting viral host cell entry by disrupting ACE2 binding with the SARS-CoV-2 spike protein. This work focuses on the potential to inhibit SARS-CoV-2 entry through a hypothesized α5β1 integrin-based mechanism, and indicates that inhibiting the spike protein interaction with α5β1 integrin (+/- ACE2), and the interaction between α5β1 integrin an
Document: Many efforts to design and screen therapeutics for the current severe acute respiratory syndrome coronavirus (SARS-CoV-2) pandemic have focused on inhibiting viral host cell entry by disrupting ACE2 binding with the SARS-CoV-2 spike protein. This work focuses on the potential to inhibit SARS-CoV-2 entry through a hypothesized α5β1 integrin-based mechanism, and indicates that inhibiting the spike protein interaction with α5β1 integrin (+/- ACE2), and the interaction between α5β1 integrin and ACE2 using a novel molecule ATN-161 represents a promising approach to treat COVID-19.
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