Author: C Langelier; MS Zinter; K Kalantar; GA Yanik; S Christenson; B Odonovan; C White; M Wilson; A Sapru; CC Dvorak; S Miller; CY Chiu; JL DeRisi
Title: Metagenomic Sequencing Detects Respiratory Pathogens in Hematopoietic Cellular Transplant Patients Document date: 2017_1_24
ID: km0b1z64_53
Snippet: Broadspectrum antibiotic overuse is frequently driven by suspicion for occult pathogens missed by standard diagnostic testing. For instance, patient 1, whose conventional testing While these results are highly encouraging, this proof-of-concept study suggests many routes for further improvement. First, this study was limited by a relatively small sample size, only one case of culture-positive bacterial LRTI, no fungal infections, and no subjects .....
Document: Broadspectrum antibiotic overuse is frequently driven by suspicion for occult pathogens missed by standard diagnostic testing. For instance, patient 1, whose conventional testing While these results are highly encouraging, this proof-of-concept study suggests many routes for further improvement. First, this study was limited by a relatively small sample size, only one case of culture-positive bacterial LRTI, no fungal infections, and no subjects with clinically diagnosed non-infectious airway diseases. Future studies with larger cohorts will be needed to validate the sensitivity and specificity of mNGS for LRTI diagnosis in this population.
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