Rapid viral diagnosis and ambulatory management of suspected COVID-19 cases presenting at the infectious diseases referral hospital in Marseille, France, - January 31st to March 1st, 2020: A respiratory virus snapshot

Amrane, Sophie; Tissot-Dupont, Hervé; Doudier, Barbara; Eldin, Carole; Hocquart, Marie; Mailhe, Morgane; Dudouet, Pierre; Ormières, Etienne; Ailhaud, Lucie; Parola, Philippe; Lagier, Jean-Christophe; Brouqui, Philippe; Zandotti, Christine; Ninove, Laetitia; Luciani, Léa; Boschi, Céline; La Scola, Bernard; Raoult, Didier; Million, Matthieu; Colson, Philippe; Gautret, Philippe

BACKGROUND: Rapid virological diagnosis is needed to limit the length of isolation for suspected COVID-19 cases. METHOD: We managed the first 280 patients suspected to have COVID-19 through a rapid care circuit and virological diagnosis in our infectious disease reference hospital in Marseille, France. Rapid viral detection was performed on sputum and nasopharyngeal samples. RESULTS: Over our study period, no SARS-CoV-2 was detected. Results were obtained within approximately 3 h of the arrival of patient samples at the laboratory. Other viral infections were identified in 49% of the patients, with most common pathogens being influenza A and B viruses, rhinovirus, metapneumovirus and common coronaviruses, notably HKU1 and NL63. CONCLUSION: Early recognition of COVID-19 is critical to isolate confirmed cases and prevent further transmission. Early rule-out of COVID-19 allows public health containment measures to be adjusted by reducing the time spent in isolation.